Beschreibung
Contractor for ADME - enzymology and DDI (f/m/d) - enzyme biochemistry / kinetics assessment / radio-HPLC / data analysis / EnglishProject:
For our customer a big pharmaceutical company in Basel we are looking for a highly qualified SContractor for ADME - enzymology and DDI (f/m/d).
Background:
Working principally on small molecule projects, we are looking for a motivated candidate to fill the gaps in the ADME field for drug development. A position is available for a 1-year contractor to work on advancing in vitro assay techniques to estimate fractions metabolized by enzymes to support clinical PK prediction and drug-drug interaction (DDI) risk assessment for small molecules portfolios.
The perfect candidate:
This role requires strong communication skills, the ability to work independently in a fast-paced and quickly changing environment in close collaboration with partner functions
The manager is looking for someone who is interested in a hands-on laboratory role
Tasks & Responsibilities:
- Conduct the laboratory-based assays in in vitro enzymology/DDI and allied experimental areas of small molecule drug metabolism as e.g. incubation of test substances using hepatocytes, human liver microsomes, recombinant enzymes.
* Analyzing incubation samples via LC-MS/MS and radio-HPLC, including bioanalytical method development and/or validation.
* Plan, monitor, communicate and report enzymology/DDI studies both in a drug discovery and drug development setting reporting to the respective laboratory staff and supervisors.
* Perform rigorous verification and develop best practices to improve the regular enzymology/DDI assays where current approaches are inadequate.
* Some time may be spent in supporting the development of new enzyme phenotyping methodologies and approaches with the help of automation.
Must Haves:
- You have a BSc or MSc degree in chemistry, biochemistry, pharmacokinetics or equivalent discipline with an interest in drug metabolism, pharmacokinetics (DMPK) and pharmacodynamics (PD) (recent PhDs might be taken into consideration if they are aware that this is a purely laboratory position, however candidates with just a BSc/MSc are strongly preferred)
* You gained good knowledge of metabolic enzyme biochemistry (e.g. CYP450, UGT), hands-on/experimental enzyme kinetics assessment and the respective experimental designs.
* Experience in bioanalytical method development/validation for radio-HPLC (e.g. Thermo®) and LC-MS/MS (e.g. Sciex®). This includes troubleshooting and data analysis (e.g.using Analyst® software).
* ?You have a strong interest in translational approaches leveraging in vitro data and clinical data.
* Fluent English
Nice to have:
- Previous experience working in the pharmaceutical industry, biotech or CRO
* German skills
* Working knowledge of regulatory expectations for enzymology studies (e.g. chemical inhibition, recombinant enzyme and correlation studies) is an advantage.
Reference Nr.: 923218TP
Role:Contractor for ADME - enzymology and DDI (f/m/d)
Industrie:Pharma
Workplace:Basel
Pensum: 80-100%
Start: 01.04.24
Duration: 12++
Deadline:14.02.2024
If you are interested in this position, please send us your complete dossier via the link in this advertisement. If this position does not fit your profile and you wish to be considered for another position directly, you can also send us your dossier via this ad or to jobs[at]itcag[dot]com.
Contact us for more information about our company, our positions or our attractive Payroll-Only programme: .
About us:
ITech Consult is an ISO 9001:2015 certified Swiss company with offices in Germany and Ireland. ITech Consult specialises in the placement of highly qualified candidates for recruitment in the fields of IT, Life Science & Engineering.
We offer staff leasing & payroll services. For our candidates this is free of charge, also for Payroll we do not charge you any additional fees.