Schlagwörter
Skills
B’SYS GmbH, Witterswil, Switzerland 10/2012 – 12/2019
About the company
B’SYS is a CRO providing services in fast drug screening and safety pharmacology on ion channels for pharmaceutical companies.
Study Director Electrophysiology
• Leading of preclinical studies e.g. in safety pharmacology including planning, performance and reporting; writing and maintaining SOPs
• Establishment and validation of methods
• Collaboration with national and international clients
• Regular presentation of results to audiences
• Experienced application of international OECD guidelines to ensure the good laboratory practice (GLP) in research laboratories
• Audit assistance (e.g. Swissmedic)
• Representation of the company at congresses and during customer visits
• Disciplinary and professional management of scientists, assistants and master
students; Trainer for new lab members
University of Ulm, Germany 04/2011 – 09/2012
About the research group
Prof. Birgit Liss´ group analyzes cell-specific function and gene-expression of individual neurons, to identify mechanisms of their selective (dys-) function in health and disease (e.g. Parkinson, Schizophrenia, ALS).
Research Scientist
Post-doctoral fellow: Dysregulation of KATP channels in the Parkinson’s disease DJ-1 KO mouse model. Electrophysiological characterization of PARK-mouse models and their ion channel dysregulation in Parkinson’s disease.
• Patch-Clamp recordings in acute brain slices of rodents
• Interdisciplinary collaboration with international research teams
Project leader in clinical research: Investigating the role of neuronal KATP channel variants with respect to the exploration behaviour of humans with functional magnetic resonance imaging (fMRI).
• Self-sufficient recruitment, organization and experimental supervision of fMRI recordings in humans in collaboration with the Hospital for Psychiatry and Psychotherapy III, Ulm
University of Freiburg &
University of Marburg, Germany 03/2007 – 03/2011
About the research group
Prof. Dominic Oliver investigates the interaction of membrane lipids on the functionality of ion channels.
PhD in Physiology (Mark 1.3, magna cum laude)
Title: “Quantification of the in-vivo affinity of PI(4,5)P2 effectors and sensors with the phosphoinositide phosphatase Ci-VSP.”
• Patch-Clamp recordings in cultured cells, two-electrode voltage-clamp, and giant patch recordings in oocytes
• Total internal reflection fluorescence microscopy, fluorescence microscopy
• Culture and transfection of cell lines, establishment of lenti-viruses for infection of primary cultured neurons
• Surgery of frogs for isolation of oocytes and microinjection of cRNA for heterologous protein expression
University of Kaiserslautern, Germany 10/2002 – 02/2007
Main focus
Animal physiology, molecular cell biology, biophysics
Studies of Biology (Diploma, Mark 1.4)
Title: “Electrophysiological and pharmacological characterization of neuroblastoma and HEK293 cells.”
• Drug screening on ion channels and receptors with planar-patch-clamp technique (Nanion Technologies GmbH, Munich, Germany)
• Establishment of new cell culture laboratory
• Microelectrode array recordings from primary cultured neurons
• Immunohistochemical staining of acute brain slices of rodents and primary
cultured neurons from chicken
• Protein biochemical techniques: 2D gel-electrophoresis, Western Blots, ELISA, and mass spectrometry
Hohenstaufen-Gymnasium in Kaiserslautern,
Germany (Abitur, Mark: 2.2) 08/1993 – 03/2002
Intensified courses
Biology, English, Mathematics
Teaching students 11/2006 – 09/2012
University of Freiburg, University of Ulm, Germany
• Human medicine and dentistry in practical courses in physiology (vestibulary
system, sensory systems, reflexes, hemostatics and vectorcardiography);
physiological seminar (Long-QT-Syndrome)
• Establishment of an interactive, motivating teaching technique
University of Kaiserslautern, Germany
• Animal physiology in advanced practical courses (patch-clamp-technique and
basics in pharmacology in acute brain slices), examination of term papers,
training of students for scientific talks
Assistance
University of Kaiserslautern, Germany 04/2005 – 12/2005
• study group pheromones in cooperation with BASF SE: Gas chromatography, dispenser purification, development of eco-friendly insecticides
University of Kaiserslautern, Germany 02/1999 – 12/2001
• Institute of Biotechnology and Drug Research
About the company
B’SYS is a CRO providing services in fast drug screening and safety pharmacology on ion channels for pharmaceutical companies.
Study Director Electrophysiology
• Leading of preclinical studies e.g. in safety pharmacology including planning, performance and reporting; writing and maintaining SOPs
• Establishment and validation of methods
• Collaboration with national and international clients
• Regular presentation of results to audiences
• Experienced application of international OECD guidelines to ensure the good laboratory practice (GLP) in research laboratories
• Audit assistance (e.g. Swissmedic)
• Representation of the company at congresses and during customer visits
• Disciplinary and professional management of scientists, assistants and master
students; Trainer for new lab members
University of Ulm, Germany 04/2011 – 09/2012
About the research group
Prof. Birgit Liss´ group analyzes cell-specific function and gene-expression of individual neurons, to identify mechanisms of their selective (dys-) function in health and disease (e.g. Parkinson, Schizophrenia, ALS).
Research Scientist
Post-doctoral fellow: Dysregulation of KATP channels in the Parkinson’s disease DJ-1 KO mouse model. Electrophysiological characterization of PARK-mouse models and their ion channel dysregulation in Parkinson’s disease.
• Patch-Clamp recordings in acute brain slices of rodents
• Interdisciplinary collaboration with international research teams
Project leader in clinical research: Investigating the role of neuronal KATP channel variants with respect to the exploration behaviour of humans with functional magnetic resonance imaging (fMRI).
• Self-sufficient recruitment, organization and experimental supervision of fMRI recordings in humans in collaboration with the Hospital for Psychiatry and Psychotherapy III, Ulm
University of Freiburg &
University of Marburg, Germany 03/2007 – 03/2011
About the research group
Prof. Dominic Oliver investigates the interaction of membrane lipids on the functionality of ion channels.
PhD in Physiology (Mark 1.3, magna cum laude)
Title: “Quantification of the in-vivo affinity of PI(4,5)P2 effectors and sensors with the phosphoinositide phosphatase Ci-VSP.”
• Patch-Clamp recordings in cultured cells, two-electrode voltage-clamp, and giant patch recordings in oocytes
• Total internal reflection fluorescence microscopy, fluorescence microscopy
• Culture and transfection of cell lines, establishment of lenti-viruses for infection of primary cultured neurons
• Surgery of frogs for isolation of oocytes and microinjection of cRNA for heterologous protein expression
University of Kaiserslautern, Germany 10/2002 – 02/2007
Main focus
Animal physiology, molecular cell biology, biophysics
Studies of Biology (Diploma, Mark 1.4)
Title: “Electrophysiological and pharmacological characterization of neuroblastoma and HEK293 cells.”
• Drug screening on ion channels and receptors with planar-patch-clamp technique (Nanion Technologies GmbH, Munich, Germany)
• Establishment of new cell culture laboratory
• Microelectrode array recordings from primary cultured neurons
• Immunohistochemical staining of acute brain slices of rodents and primary
cultured neurons from chicken
• Protein biochemical techniques: 2D gel-electrophoresis, Western Blots, ELISA, and mass spectrometry
Hohenstaufen-Gymnasium in Kaiserslautern,
Germany (Abitur, Mark: 2.2) 08/1993 – 03/2002
Intensified courses
Biology, English, Mathematics
Teaching students 11/2006 – 09/2012
University of Freiburg, University of Ulm, Germany
• Human medicine and dentistry in practical courses in physiology (vestibulary
system, sensory systems, reflexes, hemostatics and vectorcardiography);
physiological seminar (Long-QT-Syndrome)
• Establishment of an interactive, motivating teaching technique
University of Kaiserslautern, Germany
• Animal physiology in advanced practical courses (patch-clamp-technique and
basics in pharmacology in acute brain slices), examination of term papers,
training of students for scientific talks
Assistance
University of Kaiserslautern, Germany 04/2005 – 12/2005
• study group pheromones in cooperation with BASF SE: Gas chromatography, dispenser purification, development of eco-friendly insecticides
University of Kaiserslautern, Germany 02/1999 – 12/2001
• Institute of Biotechnology and Drug Research
Projekthistorie
Reisebereitschaft
Verfügbar in den Ländern
Deutschland, Österreich und Schweiz
Freiburg
DE
DE
